From aging to Alzheimer's disease: concordant brain DNA methylation changes in late life.

ABSTRACT: Aging is the strongest risk factor for Alzheimer's disease (AD), yet the molecular mechanisms linking aging to AD remain poorly understood. DNA methylation (DNAm) is an epigenetic modification that plays a critical role in gene regulation and has been implicated in both aging and AD. In this study, we performed a meta-analysis of DNAm profiles in the prefrontal cortex using two large, independent postmortem brain cohorts, the Religious Orders Study and Memory and Aging Project (ROSMAP) and Brains for Dementia Research (BDR), to identify DNAm differences associated with aging in late life. We identified 3,264 CpGs significantly associated with aging, the majority of which were hypermethylated and enriched in promoter regions and CpG islands. These aging-associated DNAm changes were signific

SUBMITTER: Lukacsovich D 

PROVIDER: S-EPMC12204281 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature