Quantifying the impact of early-life growth adversity on later-life health.

ABSTRACT:

Background

Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height ("height-GaP") would associate with prospectively ascertained early-life growth adversity and later-life all-cause and cardiovascular mortality.

Methods

Data were first analyzed from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UKBiobank. Genotype-predicted height was calculated using a multi-ancestry polygenic height score. Height-GaP was calculated as the difference between measured and genotype-predicted adult height. Early-life growth conditions were ascertained prospectively via standardized procedures (ALSPAC) and mortality via death re

SUBMITTER: Goldman-Pham R 

PROVIDER: S-EPMC12204282 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature