Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits.

ABSTRACT: The ability to override prepotent actions is critical to control impulses and adjust behavior depending on goals and contextual needs. In this study, we investigate the inhibitory control abilities of a patient diagnosed with Klüver-Bucy Syndrome following a left temporal resection. The patient presented with disruptive hypersexuality symptoms akin to compulsions, leading to the inability to control and suppress inappropriate actions. The patient was recruited for the current research study while undergoing intracranial monitoring for epilepsy, to investigate the cognitive and neural processes underlying the patient's inhibitory control symptoms. We formulated the hypothesis that an inhibitory control deficit emerges in response to provocative triggers, and we designed a personalized parad

SUBMITTER: Mattar LS 

PROVIDER: S-EPMC12204416 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature