Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages.

ABSTRACT: Brain age estimated from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate the current state of health and be predictive of future disease onset and detrimental changes in brain biology. In this preregistered study, we evaluated and compared the clinical validity, i.e., diagnostic and prognostic performance, of six publicly available brain age prediction packages using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Baseline brain age differed significantly between groups consisting of individuals with normal cognitive function, mild cognitive impairment, and Alzheimer's disease for all packages, but with comparable performance to estimates of gray

SUBMITTER: Dorfel RP 

PROVIDER: S-EPMC12204421 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature