Campus-based genomic surveillance uncovers early emergence of a future dominant A(H3N2) influenza clade.

ABSTRACT: We conducted genomic surveillance of seasonal influenza during the 2022-2023 northern hemisphere flu season on a large university setting in Southwest Arizona USA to understand the diversity, evolution, and spread within a local environment and how it relates to national data. Through high-throughput sequencing and bioinformatics, we identified 100 positive samples (19%) from 516 clinical swabs collected at the student health clinic. We observed a dominance of subtype A(H3N2) which was consistent nationally for the 2022-2023 season. However, we found stark differences when examining subtype-specific H3 clades, which included an early dominance of clade 2a.3a.1 variants contrasting from country-level data in which 2b variants were most abundant. These variants might have contributed to the

SUBMITTER: Scotch M 

PROVIDER: S-EPMC12204437 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature