Striatal Dopamine and Skeletal Muscle Energy Metabolism in Older Adults.

ABSTRACT: Dopamine (DA) in the central nervous system is considered a master regulator of mobility performance and vigor, but its mechanistic relationship with skeletal muscle energetics is unclear. We tested the cross-sectional association of striatal DA and skeletal muscle mitochondrial function in 146 older adults participating in the Study of Muscle, Mobility and Aging (75.4 years old, 54% women). Striatal DA was measured using (+)-a-[¹¹C] dihydrotetrabenazine (DTBZ) PET imaging for the limbic, sensorimotor, and executive control subregions. Mitochondrial capacity to produce ATP (ATP_max, mM ATP/s) was measured in vivo using ³¹P magnetic resonance spectroscopy after repeated voluntary muscle contractions. Ex-vivo respirometry assays from biopsies of resting

SUBMITTER: Rosano C 

PROVIDER: S-EPMC12204456 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature