Association of aortic valve calcium with dementia and stroke: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background and aims

Calcific aortic valve disease is associated with increased thrombin formation, platelet activation, decreased fibrinolysis, and subclinical brain infarcts. We examined the long-term association of aortic valve calcification (AVC) with newly diagnosed dementia and incident stroke in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods

AVC was measured using non-contrast cardiac CT at Visit 1. We examined AVC as a continuous (log-transformed) and categorical variable (0, 1-99, 100-299, ≥300). Newly diagnosed dementia was adjudicated using International Classification of Disease codes. Stroke was adjudicated from medical records. We calculated absolute event rates (per 1000 person-years) and multivariable adjusted Cox proportional hazards ratios (HR).

SUBMITTER: Marrero N 

PROVIDER: S-EPMC12204566 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature