In-silico analysis of CEP55/E2F1/hsa-let-7b-5p/TMPO-AS1 axis-based ceRNA network promoting poor prognosis in lung adenocarcinoma smokers.

ABSTRACT:

Introduction

Smoking causes severe lung adenocarcinoma. High CEP55 expression correlates with clinico-pathological features, suggesting the mRNA/miRNA/lncRNA-ceRNA network's crucial to prognosis.

Methods

The study used databases like TIMER 2.0, UALCAN, OncoMX, GEPIA2, OncoDB, ENCORI, KM Plotter, TNMplot, CancerSEA, CellTracer, GENI, Intogen, miRNet, TISIDB, GSCA, the Enrichr, HDOCK, and LigPlot databases to analyze CEP55 and associated ceRNA expression in lung cancer tumors and normal tissues.

Results

The CEP55 gene is overexpressed in both lung squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD). Findings suggested that overexpression of CEP55 has a poor prognosis in terms of overall survival (OS) (HR=1.63, CI=1.44-1.84, P=1.4e-15), first progression (FP)

SUBMITTER: Vats P 

PROVIDER: S-EPMC12204813 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature