Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.

ABSTRACT: Ischemic stroke (IS) leads to the disruption of blood-brain barrier (BBB) integrity, resulting in brain edema. In this process, endothelial cells, as a crucial component of the BBB, are subjected to external pressure and tensile stress. Piezo1, a mechanically-sensitive ion channel, may be activated by sensing these stresses, further exacerbating the destruction of the BBB. Our findings indicated that after cerebral ischemia/reperfusion (I/R) injury, the expression of Piezo1 in endothelial cells increased. In endothelial-specific Piezo1 knockout (Piezo1^ECKO) mice, brain damage, neurological deficits, and BBB disruption caused by I/R injury were significantly alleviated. Moreover, oxidative stress and the inflammatory response in the cerebral cortex induced by I/R were also reduce

SUBMITTER: Fu H 

PROVIDER: S-EPMC12204977 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature