Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2) CreERT2.

ABSTRACT: Neuronal migration during embryonic development is a fundamental process. In the developing nose of rodents, neurons that form during early neurogenic waves in the olfactory placode leave this structure to migrate toward or into the developing brain as part of the migratory mass. This mass includes gonadotropin-releasing hormone-1 (GnRH-1) neurons, pioneer/terminal nerve (TN) neurons, as well as neural crest-derived olfactory glial cells called olfactory ensheathing cells. There have been a limited number of molecular markers available to effectively trace and functionally manipulate the early migratory neurons that originate in the olfactory region. Contactin-2 (Cntn2), also known as transiently expressed axonal surface glycoprotein-1 (TAG-1), has been used to label various developing neu

SUBMITTER: Amato E 

PROVIDER: S-EPMC12205475 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature