Cumulative remnant cholesterol and major adverse cardiovascular events among adults with type 2 diabetes.

ABSTRACT:

Background

Individuals with type 2 diabetes are prone to dyslipidemia. The relationship of cumulative exposure to elevated remnant cholesterol (RC) with major adverse cardiovascular events (MACEs) remains unclear for individuals with type 2 diabetes, especially for those with intensive lipid-lowering treatment.

Methods

This study included 5143 participants with type 2 diabetes from the Action to Control Cardiovascular Risk in Diabetes trial, who had at least four lipid measurements over the first three years of the trial and did not have MACEs across the measurements. Cumulative RC (cumRC) was calculated considering RC levels at each measurement and the between-measurement time interval. Cox proportional hazards regression models were used to estimate HRs and 95 % CIs of MAC

SUBMITTER: Qian YW 

PROVIDER: S-EPMC12205595 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature