Genetically engineered bio-composite mediated dual-modality imaging-guided synergistic chemo-FUAS for tumor therapy.

ABSTRACT: Focused ultrasound ablation surgery (FUAS) combined with bacterial synergistic therapy has significant potential in solid tumors, however, this combination therapy has been limited mainly due to its weak anti-tumor effects, single imaging modality, and exhibition of tumor recurrence. Herein, we aim to develop a novel multifunctional bio-composite comprising the coating of polydopamine (pDA) and doxorubicin (DOX) on the surface of genetically engineered bacteria (GVs-E. coli) for the ultrasound imaging (USI) and photoacoustic imaging (PAI)-guided synergistic chemo-FUAS therapy of tumor. The bio-composite preferentially colonize into hypoxic tumor tissues, the gas vesicles (GVs) expressed in GVs-E. coli can effectively synergize to FUAS through their cavitation effect and perfo

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12205684 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature