Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions.

ABSTRACT: Research on genetic and environmental influences on brain function generally focuses on connections between brain areas. A different yet unexplored approach is to examine activity within local brain regions. We investigated the influence of genes and environmental effects on two specific measures of local brain function: regional homogeneity and fractional amplitude of low-frequency fluctuations. Participants were drawn from a sample of adolescent twins on two occasions (mean ages 11.5 and 13.2 yr, n = 278 and 248). Results showed that genetic and environmental factors influenced brain function in almost all 210 cortical regions examined. Moreover, genetic and common environmental factors influencing regional homogeneity and fractional amplitude of low-frequency fluctuation values at wave

SUBMITTER: Strike LT 

PROVIDER: S-EPMC12205945 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature