CircNRIP1 impairs tumorigenesis of colorectal cancer by sponging IGF2BP1 and decreasing <i>NACC1</i> mRNA stability.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide. Early diagnosis is critical in CRC treatment. More convenient and accurate biomarkers for early diagnosis are needed. However, whether circular RNAs (circRNAs) participate in colorectal tumorigenesis and their role in early diagnosis of CRC remain unknown.

Methods

We investigated the deregulated circRNAs and CRC-specific blood exosomal circRNAs in the Gene Expression Omnibus database and exoRBase. Functional assays were performed to evaluate the effects of hsa_circ_0004771 (circNRIP1) on proliferation and tumorigenesis both in vitro and in vivo. RNA pull-down, proteomic analysis, and RNA immunoprecipitation-polymerase chain reaction were performed to explore the underlying biol

SUBMITTER: Han K 

PROVIDER: S-EPMC12205946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature