<i>miR-222</i> and <i>miR-146a</i> Variants in Idiopathic Male Infertility: A Case-Control Study.

ABSTRACT:

Background

Idiopathic Male Infertility is a widespread problem affecting approximately 10 to 15 percent of men of reproductive age. Several genes have been studied related to idiopathic male infertility. Thereafter, among the family of non-coding RNAs, microRNAs are shown to play a very important role in the regulation of a subset of genes. It has been documented that infertile men have differentially expressed miRNA. The aim of this study is to evaluate the impact of two genetic variants, miR-222 rs2858060 and miR-146a rs2910164 on idiopathic male infertility.

Materials and methods

In this case-control study, Blood samples were taken from 201 men with idiopathic infertility and 201 men in a healthy state for this case-control investigation. Genotype determinat

SUBMITTER: Hoseini ZS 

PROVIDER: S-EPMC12206353 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature