Surveillance donor-specific antibody and pathologic antibody-mediated rejection testing in heart transplant patients in the contemporary era.

ABSTRACT:

Background

Surveillance donor-specific antibody (DSA) and pathologic antibody-mediated rejection (pAMR) testing is recommended in the first year after heart transplantation (HTx) in adult patients. Whether pAMR testing adds prognostic information to contemporary DSA testing has not been fully studied.

Methods

This was a single-center study of consecutive endomyocardial biopsies (EMB) performed between November 2010 and February 2023 in adult HTx patients. The primary objective was to evaluate whether pAMR testing contributes additional information to DSA testing to better predict overall survival. Secondary end-points included cardiac survival and allograft dysfunction.

Results

A total of 6,033 EMBs from 544 HTx patients were reviewed for the study. The pAMR+/DSA+ pat

SUBMITTER: Cusi V 

PROVIDER: S-EPMC12206481 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature