Autoantibodies Against Collapsin Response Mediator Proteins Associated With Encephalopathy/Myelopathy: A Single-Center Retrospective Study.

ABSTRACT:

Background

Collapsin response mediator protein (CRMP) consists of five subtypes (CRMP1-5), which share high homology and are expressed in the nervous system. Anti-CRMP2 and anti-CRMP5 antibodies (Abs) have been reported in autoimmune encephalitis (AE). This study retrospectively evaluated the diagnostic value of CRMP auto-Abs in patients with suspected immune-mediated encephalopathy/myelopathy.

Methods

Patients with encephalopathy/myelopathy attributed to autoimmune or infectious causes, as well as those with encephalopathy of unclear etiology, were recruited from our department between January 2017 and November 2019. Clinical data, as well as serum and/or cerebrospinal fluid (CSF) samples, were collected. Measurement of Abs against CRMPs in patient samples was performed usi

SUBMITTER: Wang D 

PROVIDER: S-EPMC12206659 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature