A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus.

ABSTRACT:

Objectives

As the aging population grows, Alzheimer's disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.

Methods

We conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals.

Results

A multilevel random-effects meta-analysis of six longitudinal studies using 13 effect

SUBMITTER: Hwang SA 

PROVIDER: S-EPMC12206670 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature