Lipid metabolic adaptations during inflammation are controlled by the circadian clock and impaired by light at night.

ABSTRACT:

Objective and design

Immune defence requires systemic metabolic changes to redirect energy and nutrients to activated immune cells. The circadian clock is known to control the immune response, but its role in regulating metabolic adaptations following the immune challenge remains poorly understood. We aimed to examine the inflammatory and metabolic responses in rat liver and visceral white adipose tissue (vWAT) after time-of-day-dependent endotoxin stimulation under a regular light/dark cycle or dim artificial light at night (ALAN; ~2 lx), which disrupts immune and metabolic rhythms. Male rats were challenged with lipopolysaccharide (LPS) either during the day or night and acute changes in metabolic pathways and the peripheral metabolic clocks were analysed at both systemic and mol

SUBMITTER: Benedikova B 

PROVIDER: S-EPMC12206677 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature