Oral bacterial community dynamics during induction of gingival inflammation.

ABSTRACT:

Introduction

The human oral cavity is a complex and dynamic microbial ecosystem integral to oral and overall health. While the specific roles of microbial communities in health and disease are not fully understood, dysbiosis of the oral microbiota is, along with inadequate immune fitness, recognized as a key factor driving the onset of inflammatory conditions such as gingivitis. Gingivitis, an early and reversible stage of periodontal disease, involves shifts in microbial composition and diversity. This study aimed to investigate the compositional dynamics of the oral microbiota during the early stages of gingival inflammation, focusing on changes across multiple oral niches and their relationship to clinical outcomes.

Methods

We conducted an experimental gingivitis interven

SUBMITTER: Keijser BJF 

PROVIDER: S-EPMC12206739 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature