Gut microbiota orchestrates skeletal muscle development and metabolism in germ-free and SPF pigs.

ABSTRACT: The gut microbiota, as a crucial symbiotic microbial community in the host, participates in regulating the host's metabolism, immunity, and tissue development. Skeletal muscle is a key tissue for movement and energy metabolism in the body, with its development and function regulated by multiple factors; however, the molecular mechanisms by which the gut microbiota influences skeletal muscle remain unclear. This study utilized germ-free (GF) and specific pathogen-free (SPF) pig models, combined with multiple analytical approaches, to systematically investigate the effects of gut microbiota absence on skeletal muscle development, muscle fiber typing, and metabolism. The study found that skeletal muscle development in GF pigs was impaired, with significant changes in muscle fiber diameter and

SUBMITTER: Li Z 

PROVIDER: S-EPMC12206747 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature