<i>Lactobacillus plantarum</i> SAL delays aging-associated oxidative stress and gut microbiota dysbiosis in mice.

ABSTRACT:

Introduction

Lactobacillus plantarum SAL, isolated from multidrug-resistant patients' feces, exhibits superior in vitro probiotic traits including bile salt resistance, gastric acid tolerance, and potent antioxidant capacity. While Lactobacillus plantarum generally enhances gut microbiota structure/function, improving health and lifespan in model organisms, the in vivo effects, mechanisms, and potential anti-aging properties of the SAL strain remain unexplored. This study addresses this critical research gap.

Methods

Twenty-four SPF KM male mice were divided into a control group (CON), model group (MOD), and a SAL strain intervention group (SAL). MOD and SAL groups received d-gal-induced aging models. SAL group was orally administered SAL strain suspension dail

SUBMITTER: Dong W 

PROVIDER: S-EPMC12206855 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature