γδ⁺ T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F⁺ neutrophil development in PPE-induced emphysema.

ABSTRACT: Neutrophils play a pivotal role in the progression of IL-17-mediated airway inflammation, but the mechanisms underlying their pathological differentiation remain poorly understood. In this study, we identified a distinct population of lung-specific pathogenic Siglec-F⁺ neutrophils in a porcine pancreatic elastase (PPE)-induced mouse model of emphysema. Compared with conventional neutrophils, these Siglec-F⁺ neutrophils exhibited increased phagocytic activity, increased extracellular trap formation, increased production of proinflammatory cytokines, and reduced IL-10 levels. During the early phase of acute inflammation following PPE instillation, IL-17A levels in the lungs increase, which is driven primarily by γδ⁺ T cells. IL-17A stimulated lung epithelial/

SUBMITTER: Hong J 

PROVIDER: S-EPMC12206919 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature