Induction of Apoptosis by Ethanol, Methanol, and Ethyl Acetate Extracts from <i>Cyperus Rotundus'</i> Leaf on <i>In Vitro</i> Human Ovarian, Cervix, and Breast Cancer Cell Lines.

ABSTRACT:

Background

Cervical, breast, and ovarian cancers exhibit significant incidence and fatality rates, necessitating diverse approaches for effective cancer cell eradication while preserving normal cells. The aim of this study is to explore the in vitro apoptosis-inducing properties of hydroalcoholic extracts from Cyperus rotundus' (C. rotundus) leaf using human gynecological cancer cell lines.

Materials and methods

In this experimental study, Hydroalcoholic extracts were prepared from the leaf of C. rotundus using ethanol, methanol, and ethyl acetate. These extracts were applied to MCF-7, HeLa, OVCAR-3, and Vero cell lines at concentrations of 3.125, 6.25, 12.5, and 25 g/ml. MTT test, assessing inhibition of proliferation at 50% (IC₅₀), was employed to

SUBMITTER: Moradi Kooshkmeydani M 

PROVIDER: S-EPMC12207328 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature