The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine.

ABSTRACT: The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria that are acquired from the gut microbiome and/or diet in humans. Following cellular uptake, Q is incorporated at the wobble base (position 34) of tRNAs that decode histidine, tyrosine, aspartate, and asparagine codons, which is important for efficient translation. Early studies suggested that cytosolic uptake of queuine is mediated by a selective transporter that is regulated by mitogenic signals, but the identity of this transporter has remained elusive. Here, through a cross-species bioinformatic search and genetic validation, we have identified the solute carrier family member SLC35F2 as a unique transporter for both queuine and queuosine in Schizosaccharomyces pombe and Trypan

SUBMITTER: Burtnyak L 

PROVIDER: S-EPMC12207525 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature