Exploring Linear <i>mono</i>-, <i>bis</i>- and <i>tris</i>-Acetylene Containing Agonists of the Human Olfactory Receptor OR1A1.

ABSTRACT: Structure-activity relationship studies on olfactory receptors such as OR1A1 enhance an understanding of the molecular mechanism of olfactory perception. Such receptors are considered to be important in regulating physiological roles beyond olfactory perception. Here a series of linearized ketones, alcohols, and a cyclic ether, extended between the oxygen functionality and a terminal tert-butyl group with either mono-, bis-, or tris-acetylene spacers, was prepared to explore the response of human olfactory receptor OR1A1. The best agonists were bis-acetylene rods combined with an aryl spacer, including the bis-acetylene ketones 13 and 14, as well as the primary aryl-bis-acetylene alcohol 20 and the corresponding secondar

SUBMITTER: Liu W 

PROVIDER: S-EPMC12207589 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature