LncRNA <i>C5orf64</i> polymorphisms (rs12518552 and rs2950218) decreases pulmonary tuberculosis susceptibility.

ABSTRACT:

Background

Pulmonary tuberculosis (PTB) remains a significant global health issue, with genetic factors playing a crucial role in susceptibility. Long noncoding RNA (lncRNA) C5orf64 has been implicated in immune responses and cancer, but its association with PTB risk has not been fully explored.

Methods

Genomic DNA was extracted from peripheral blood samples of 955 participants (474 PTB cases and 481 controls). Rs12518552 and rs2950218 in C5orf64 were genotyped using the Agena MassARRAY system. Logistic regression analysis was performed to assess the association between these polymorphisms and PTB risk. Stratified analysis was conducted to evaluate the influence of age, gender, and smoking status.

Results

Rs12518552-G (OR = 0.82, p = 0.034) and rs

SUBMITTER: Xu S 

PROVIDER: S-EPMC12207763 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature