1,25-Dihydroxy vitamin D₃ inhibits LPS-mediated inflammatory responses in endometriosis.

ABSTRACT:

Background

Endometriosis, a chronic immune-mediated inflammatory disease, remains elusive in its pathogenesis. Given vitamin D (VD)'s pivotal role in modulating innate and adaptive immune responses, we sought to elucidate how VD modulates inflammatory responses in endometriosis.

Materials and methods

We isolated primary human ectopic endometrial stromal cells (EESCs) from ectopic endometrium of ovarian endometrioma, alongside Ishikawa cells, and subjected them to treatment with lipopolysaccharide (LPS), a potent inducer of inflammation, alongside varying concentrations of 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), the biologically active form of VD, and its analog TEI-9647 (25-dehydro-1α-hydroxyvitamin D₃-26,23-lactone).

Results

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC12207774 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature