Exploring the Molecular Mechanisms of Autophagy-related Genes in Hepatic Ischemia/Reperfusion Injury Using Bioinformatics.

ABSTRACT:

Background

Autophagy is a highly conserved cellular process. In the context of hepatic ischemia/reperfusion injury (HIRI), dysregulation of autophagy may lead to hepatocyte dysfunction. Therefore, we conducted a comprehensive transcriptomics analysis to investigate the biomolecular mechanisms underlying autophagy in HIRI.

Methods

Bioinformatics were used to analyze the GSE112713 data set, with the objective of identifying the differential expression of autophagy-related genes (DEARGs). The expression and diagnostic potential of DEARGs were validated using in vitro models and receiver operating characteristic curves. Additionally, potential therapeutic drugs targeting DEARGs were predicted.

Results

Transcriptome bioinformatics analysis revealed widespread dysregulation

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC12208648 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature