CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration.

ABSTRACT:

Background

Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease mainly affecting the colon. The exact etiology of UC remains elusive. CD131 is a receptor subunit mediating the effects of hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and Interleukin-3 (IL-3), which regulate various inflammatory responses. The pleiotropic effects of the cytokines on intestinal inflammation suggest that additional factors influence their overall function, where the receptor may play a role.

Methods

In the present study, we investigated the role of CD131 in the pathogenesis of UC, with the use of murine colitis model established by administration of dextran sulfate sodium (DSS) in the drinking water.

Results

By comparing the imm

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12208661 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature