Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism.

ABSTRACT: m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the forces underlying such modulation. Prior work has focused on investigating active mechanisms governing m6A levels, such as recruitment of m6A writers or erasers leading to either 'global' or 'site-specific' modulation. Here, we propose that changes in m6A levels across subcellular compartments and biological trajectories may result from passive changes in gene-level mRNA metabolism. To predict the intricate interdependencies between m6A levels, mRNA localization, and mRNA decay, we establish a differential model 'm6ADyn' encompassing mRNA transcription, met

SUBMITTER: Dierks D 

PROVIDER: S-EPMC12208664 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature