Identification of polymorphisms associated with attenuation of Vif and Vpr in HIV-1 Elite Controllers.

ABSTRACT:

Background

Elite controllers (ECs) are a rare subset of individuals who naturally suppress human immunodeficiency virus type 1 (HIV-1) replication in the absence of antiretroviral therapy. Specific polymorphisms in the accessory proteins Vif and Vpr have been associated with diminished viral fitness in vitro and are more frequently detected in ECs compared to other individuals infected with HIV-1.

Objective

To assess the frequency of gross genetic defects or polymorphisms that may attenuate the function of the HIV-1 accessory proteins Vif and Vpr within the proviral quasispecies of ECs.

Methods

We performed single-genome amplification (SGA) and sequence analysis of the proviral quasispecies of the accessory genes vif and vpr in samples obtained from eight ECs with ove

SUBMITTER: de Azevedo SSD 

PROVIDER: S-EPMC12208676 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature