Regulation of presynaptic homeostatic plasticity by glial signalling in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD), the most common form of dementia among the elderly, affects numerous individuals worldwide. Despite advances in understanding the molecular underpinnings of AD pathology, effective treatments to prevent or cure the disease remain elusive. AD is characterized not only by pathological hallmarks such as amyloid plaques and neurofibrillary tangles but also by impairments in synaptic physiology, circuit activity and cognitive function. Synaptic homeostatic plasticity plays a vital role in maintaining the stability of synaptic and neural functions amid genetic and environmental disturbances. A key component of this regulation is presynaptic homeostatic potentiation, where increased presynaptic neurotransmitter release compensates for reduced postsynaptic glutamate recep

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12208685 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature