Genome-wide investigation of exogenous female hormones, genetic variation, and venous thromboembolism risk.

ABSTRACT:

Background

Increased risk of venous thromboembolism (VTE) is a life-threatening side effect for users of oral contraceptives (OCs) or hormone therapy (HT).

Objectives

To investigate the potential for genetic predisposition to VTE in OC or HT users, we conducted a gene-by-environment case-only meta-analysis of genome-wide association studies (GWAS).

Methods

Use or nonuse of OCs (7 studies) or HT (8 studies) at the time of the VTE event was determined by pharmacy records or self-report. A synergy index (SI) was modeled for each variant in each study and submultiplicative/supramultiplicative gene-by-environment interactions were estimated. The SI parameters were first meta-analyzed across OC and HT studies and subsequently meta-analyzed to obtain an overall estimate. The

SUBMITTER: Hasser EK 

PROVIDER: S-EPMC12208689 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature