Near-universal prevalence of central adiposity in heart failure with preserved ejection fraction: the PARAGON-HF trial.

ABSTRACT:

Background and aims

An expansion of fat mass is an integral feature of patients with heart failure and preserved ejection fraction (HFpEF). While body mass index (BMI) is the most common anthropometric measure, a measure of central adiposity-the waist-to-height ratio (WHtR)-focuses on body fat content and distribution; is not distorted by bone or muscle mass, sex, or ethnicity; and may be particularly relevant in HFpEF.

Methods

The PARAGON-HF trial randomized 4796 patients with heart failure (HF) and ejection fraction ≥45% to valsartan or sacubitril/valsartan. The current work characterizes the association of BMI and WHtR with clinical features, outcomes, and the response to neprilysin inhibition.

Results

About half (49%) of the participants were considered obese by B

SUBMITTER: Peikert A 

PROVIDER: S-EPMC12208775 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature