Natriuretic response prediction equation for use with oral diuretics in heart failure.

ABSTRACT:

Background and aims

Limited data are available to assess oral diuretic response in outpatients with heart failure (HF). The natriuretic response prediction equation (NRPE) predicts natriuresis following a loop diuretic dose using a urine sample 2 h after the dose and was validated to accurately predict intravenous diuretic response. The primary aim was to validate the NRPE's assessment of oral diuretic response in patients with HF.

Methods

The NRPE was evaluated in two HF patient cohorts receiving oral loop diuretics: Mechanisms of Diuretic Resistance (MDR) and TRANSFORM-Mechanism. Participants received their home oral loop diuretic followed by a supervised timed urine collection including spot urine samples at 1 and 2 h. Patients quantified their self-assessed diuretic resp

SUBMITTER: Ivey-Miranda JB 

PROVIDER: S-EPMC12208776 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature