Thermal CO Release Reactivity of a π-Extended Flavonol Anion.

ABSTRACT: The π-extended flavonol Flav-1 (1) undergoes reaction with KOH or KO₂ to form 1^-, which reacts with O₂ at ambient temperature, resulting in CO release and depside formation. Mechanistic and DFT studies support a reaction pathway involving reaction of 1^- with O₂ on the triplet energy surface in the rate-determining step. Formation of a cyclic peroxide leads to CO extrusion. These studies indicate that if formed in biological environments, 1^- will release CO in the absence of light illumination.

SUBMITTER: Anderson SN 

PROVIDER: S-EPMC12208801 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature