Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis.

ABSTRACT: Psoriasis is a chronic inflammatory skin-disease associated with cardiovascular comorbidities. In patients, T cells with a skin-primed phenotype are expanded in peripheral blood, indicating a role for skin to blood T cell recirculation in the development of systemic comorbidities. Here, we aimed to investigate (i) the establishment of CD4⁺ and CD8⁺ T cell memory, (ii) the accumulation of activated and terminally differentiated T cells, and (iii) the potential link with vascular inflammation, in a mouse model of recurrent psoriasis. The results revealed systemic accumulation of memory T cells in the mouse model and similar results in patients with psoriatic disease. Recurrent psoriasis-like condition in mice also induced increased activation of memory T cells, augmente

SUBMITTER: Casciano F 

PROVIDER: S-EPMC12208849 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature