Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness.

ABSTRACT:

Purpose

Critically ill patients requiring intensive care unit (ICU) admission suffer from muscle weakness that persists for years, compromising quality-of-life. The pathophysiology of this long-term weakness remains unclear. We hypothesized that former ICU-patients show a long-term abnormal RNA-expression profile, which may contribute to lower long-term strength and for which modifiable risk factors can be identified.

Methods

This pre-planned secondary analysis of the EPaNIC-trial compared muscle transcriptomes of 115 former ICU-patients 5 years after critical illness and 30 matched controls with RNA-sequencing, followed by pathway over-representation and differential co-expression analyses of the differentially expressed RNAs. We used multivariable linear regression analyse

SUBMITTER: Uzun Ayar C 

PROVIDER: S-EPMC12208968 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature