The effect of implicit learning on functional connectivity in schizophrenia.

ABSTRACT:

Introduction

Neuronal plasticity, or the ability to change and adapt in response to experiences, learning, or environment, is frequently disrupted in schizophrenia and contributes to disease-associated cognitive deficits and functional impairments.

Methods

In this study, we investigated the neuroplasticity alterations of schizophrenia patients in the cortico-striato-cerebellar circuits associated with implicit learning using a reward-enhanced Serial Reaction Time Task (SRTT) by resting-state functional MRI (rs-fMRI). Forty-two schizophrenia patients and 25 healthy controls underwent pre- and post-task rs-fMRI to evaluate changes in functional connectivity.

Results

Behavioral results indicated that all participants demonstrated shorter reaction times during sequential

SUBMITTER: Hinc AC 

PROVIDER: S-EPMC12209253 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature