Multi-omics analyses reveal altered gut microbial thiamine production in obesity.

ABSTRACT:

Objective

Accumulating evidence highlights the important role of B vitamins in maintaining the balance of gut microbial ecology and metabolism, however, few studies have focused on changes in B vitamins homeostasis in the gut and their associations with disease. This study aims to investigate the potential interplay between B vitamins, gut microbiota, and obesity.

Methods

We conducted an integrated analysis of fecal shotgun metagenomics, fecal metabolome concerning B vitamins and short chain fatty acids (SCFAs), and obese phenotypes in a cohort of 63 participants, including 31 healthy controls and 32 individuals with obesity.

Results

Metabolomic analysis identified significantly lower levels of fecal thiamine in individuals with obesity (P _Wilcoxon <

SUBMITTER: Xia Y 

PROVIDER: S-EPMC12209360 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature