Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 <i>Klebsiella pneumoniae</i> during prolonged hospitalization of a single patient.

ABSTRACT:

Introduction

Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global public health challenge due to its significant association with morbidity and mortality. Ceftazidime-avibactam (CZA) has emerged as an effective therapy against CRKP producing the serine carbapenemase KPC; however, resistance driven by novel KPC variants is increasingly reported.

Methods

In this study, 27 CRKP isolates were collected from elderly pneumonia patients in China. Sequential isolates from a single patient undergoing prolonged hospitalization revealed dynamic resistance evolution.

Results

Whole-genome sequencing identified KPC-227, a novel KPC variant, alongside the previously reported KPC-204. KPC-204, carrying a "DDK" insertion at position 270, conferred resistance

SUBMITTER: Sun S 

PROVIDER: S-EPMC12209373 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature