Two Neuroanatomical Subtypes in Fibromyalgia Patients: Distinct Morphological Patterns and Treatment Outcomes.

ABSTRACT:

Objectives

To better investigate neurobiological heterogeneity in fibromyalgia for its symptom diversity and individual differences.

Methods

We collected structural MRI data and clinical characteristics of Chinese female fibromyalgia patients and healthy controls matched by age and educational level, then invited qualified patients to undergo either Ba-Duan-Jin or pregabalin intervention for 12 weeks randomly. Structural MRI was analyzed by CAT12 software, and the regional volume of gray matter (GMV) was calculated according to the Brainnetome atlas. Fibromyalgia patients were clustered using the HYDRA algorithm to detect disease subtypes.

Results

Two distinct neuroanatomical subtypes were found among 75 patients. Compared to 93 healthy controls, patients in subtype 1

SUBMITTER: Wu S 

PROVIDER: S-EPMC12209714 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature