Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis.

ABSTRACT:

Objective

To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial.

Methods

A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational cohort. The MINIMISE trial combined Morbi-mortality endpoint was used as the clinical outcome for a time to clinical worsening (TTCW) design. The IFN score was calculated from the serum concentration of chemokine C-C motif ligand (CCL) 2, CCL8, CCL19, C-X-C motif chemokine ligand (CXCL) 9, CXCL10, and CXCL11 on patients and age- and sex-matched healthy controls (HCs). A "high" IFN score was defined as 2 SDs above the HC mean. The

SUBMITTER: Di Donato S 

PROVIDER: S-EPMC12209744 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature