Antibiotic resistance and population structure of Staphylococcus epidermidis from prosthetic joint infections in Sweden and France.

ABSTRACT:

Background and objectives

Staphylococcus epidermidis is a major cause of prosthetic joint infections (PJIs). Multidrug resistant (MDR), hospital-adapted clones constitute most cases globally, though regional differences in lineage dissemination likely exist. The aim was to explore the population structure of S. epidermidis from PJIs in Sweden and France, with a focus on the presence of antimicrobial resistance (AMR).

Methods

This study included genome sequence data from 191 clinical S. epidermidis isolates collected from patients with PJI in central Sweden (2007-16; n = 138) and the Lyon region in France (2015-20; n = 53).

Results

Hospital-adapted lineages with a high burden of AMR dominated the cases in both countries. However, the ST2 lineage was significantly more

SUBMITTER: Edslev SM 

PROVIDER: S-EPMC12209789 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature