Allopurinol use predicts lower low-density lipoprotein cholesterol in patients with pre-dialysis chronic kidney disease-a prospective cohort study.

ABSTRACT:

Background

Hyperuricemia influences lipid metabolism, yet relationships between urate-lowering therapy with allopurinol, serum urate, and lipid levels in patients with chronic kidney disease remain underexplored.

Methods

This was a post-hoc analysis of 1970 participants of the CAN AIM to PREVENT who had pre-dialysis chronic kidney disease and were not receiving lipid-lowering therapy or febuxostat. Joint generalized structural equation modeling was used to investigate associations between allopurinol use (yes or no), serum urate [as a continuous or categorical variable (target if <6 mg/dl or high if ≥6 mg/dl)], and lipid levels [total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides) assessed every 6 months for

SUBMITTER: Taskapan H 

PROVIDER: S-EPMC12209807 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature