Global Transcriptional Complexity of Estrogen Receptor-Low Positive Breast Cancers in the Prospective Swedish Population-Based SCAN-B Cohort.

ABSTRACT:

Purpose

There is uncertainty whether estrogen receptor (ER)-low tumors with 1% to 10% IHC staining of nuclei represent a distinct molecular biological entity of breast cancer, posing significant challenges for their clinical management and the development of novel therapies. We aimed to elucidate ER-low tumor biology.

Experimental design

We analyzed primary breast tumors included in the Swedish population-based Sweden Cancerome Analysis Network-Breast (SCAN-B) cohort, 2% (n = 174) of which were classified as ER-low. Transcriptional patterns, tumor inflammatory infiltration, and prognosis were compared between ER-low versus ER-negative (ER-neg; 0%) and ER-positive (ER-pos; >10%) tumors.

Results

The transcriptomes of ER-low and ER-neg tumors remarkably overlapped, displ

SUBMITTER: Kimbung S 

PROVIDER: S-EPMC12209827 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature