Probing substrate binding and release events in iridium-catalysed hydrogen isotope exchange reactions.

ABSTRACT: Directed, metal-catalysed C-H activation reactions rely on the binding of a Lewis basic functional group to the metal centre to ensure precise control of regioselectivity. However, groups that bind the metal centre too strongly have the potential to decrease turnover frequency and inhibit productive catalysis. Herein, we have used kinetic studies of iridium-catalysed hydrogen isotope exchange reactions, with NMR spectroscopy and mass spectrometry as the analytical techniques, to investigate the binding and release behaviour of a representative series of monosubsituted aromatic systems bearing a Lewis basic directing group. It was found that pyridine and pyrimidine exhibit anomalous behaviour, with a single-binding/dual labelling process dominating, or at least being competitive with, a bin

SUBMITTER: Timofeeva DS 

PROVIDER: S-EPMC12209880 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature