Meal scheduling corrects obesogenic diet induced-uncoupling of cortico-hippocampal activities supporting memory.

ABSTRACT:

Background

Highly caloric food consumed around the clock perturbs the metabolism and cognitive functioning. We hypothesised that obesogenic food could alter neuronal representations of memory depending on the feeding-fasting cycle.

Methods

We tracked memory performance, dendritic spine dynamics and neuronal representations of memory in C57Bl6J mice fed obesogenic food ad libitum from peri-adolescence. We aimed to correct energy rich diet-induced plasticity deficits and cognitive impairment with time-restricted feeding in males and females. We further used chemogenetics, pharmacology and knock-in mice to investigate functional correlates underlying diet-induced neurocognitive impairments.

Findings

We found that changes in the feeding-fasting cycle reverted the effects

SUBMITTER: Chakraborty P 

PROVIDER: S-EPMC12209983 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature