Structural insights into full-length human fascin1: a target for cancer treatment.

ABSTRACT: Fascin1 proteins are a family of globular proteins with actin-bundling activity that cross-link actin filaments together, allowing the formation of actin-rich structures involved in cell migration and adhesion, such as filopodia, invadopodia, stress fibers, micro-spikes and podocytes. The overexpression of human fascin1 has been linked to tumor progression in most human cancers, particularly during the epithelial-mesenchymal transition, making it a promising biomarker for cancer metastasis and a major target for the development of novel cancer therapies. X-ray crystallography has been instrumental in human fascin1-inhibition research since it provides detailed insights into the structure of the protein and its interactions with small-molecule inhibitors. This technique has allowed the char

SUBMITTER: Giraldo-Ruiz L 

PROVIDER: S-EPMC12210192 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature